Acylation is the conversion of compounds with active hydrogens (such as –SH, –OH and –NH) into thioesters, esters and amides respectively by forming a carboxylic acid derivative. The primary use of acylation chemistry is to form compounds that chromatograph better and have a greater detectability than the parent molecule. For example, addition of a perfluoro group will improve the detectability of analytes if an electron capture detector is used.
MBTFA
N-methyl-bis-trifluoroacetamide
Part Number
SMBTFA-0-1
SMBTFA-0-10
SMBTFA-0-25
SMBTFA-0-100
Quantity
1 gm vial
10 gm vial
25 gm vial
100 gm vial
Units per pack
10
1
1
1
- This reacts with primary and secondary amines, hydroxyl and thiol groups under mild, nonacidic conditions.
- Produces very volatile derivatives of carbohydrates.
- Can be used to selectively acylate amines in the presence of hydroxyl and carboxyl groups that have been protected by silylation.
TFAA
Trifluoroacetic acid anhydride
Part Number
STFAA-0-1
STFAA-0-10
STFAA-0-25
STFAA-0-100
Quantity
1 gm vial
10 gm vial
25 gm vial
100 gm vial
Units per pack
10
1
1
1
- Reacts readily with alcohols, phenols and amines producing stable volatile derivatives for TCD, FID, ECD and other detectors. Most reactive of all the perfluoroacid anhydrides and frequently used to identify methamphetamine.
PFAA
Pentafluoropropionic acid anhydride
Part Number
SPFAA-0-1
SPFAA-0-10
SPFAA-0-25
SPFAA-0-100
Quantity
1 gm vial
10 gm vial
25 gm vial
100 gm vial
Units per pack
10
1
1
1
- Reacts readily with alcohols, phenols and amines producing stable volatile derivatives for TCD, FID. Commonly used in the determination of Benzoylecgonine and Opiates.
- Acidic by-products of this reaction must be removed before the derivative can be injected onto the GC.
HFAA
Heptafluorobutyric acid anhydride
Part Number
SHFAA-0-1
SHFAA-0-10
SHFAA-0-25
SHFAA-0-100
Quantity
1 gm vial
10 gm vial
25 gm vial
100 gm vial
Units per pack
10
1
1
1
- Reacts readily with alcohols, phenols and amines producing stable volatile derivatives for TCD, FID,ECD and other detectors.
- Used in the determination of Amphetamines and Phencyclidine.
- It is suggested that amine bases (such as triethylamine) be used to react with the acidic by-products of these to drive the reaction to completion.
TFAI - N-Trifluoroacetylimidazole
Part Number
STFA1-0-1
STFA1-0-5
Quantity
1 gm vial
5 gm vial
Units per pack
10
1
- Reacts readily with alcohols, phenols and amines producing stable volatile derivatives for TCD, FID, ECD and other detectors.
- Offer considerable advantages over the anhydrides for the preparation of perfluoroacyl derivatives; the reactions are smooth, quantitative and produce no acid byproducts.
- Principal byproduct is imidazole (relatively inert).
PIA
Propionic Anhydride
Part Number
SPIA-0-1
SPIA-0-10
SPIA-0-25
Quantity
1 gm vial
10 gm vial
25 gm vial
Units per pack
10
1
1