SELECTRA-SIL® Silylation Reagents

Silyl derivatives are the most widely used chemical derivatization reagents, especially for gas chromatography. Silyl derivatization requires an “Active” hydrogen as seen in acids, alcohols, thiols, amines, amides, enolizable ketones and aldehydes to be replaced by a trimethysilyl group or tertiary butyl dimethylsilyl.

 

BSTFA

N,O-bis(Trimethylsilyl)trifluoroacetamide

Part Number

SBSTFA-0-1

SBSTFA-0-10

SBSTFA-0-25

SBSTFA-0-100

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • Trimethylsilyl donor strength equal to BSA.
  • Reacts with the same classes of compounds as BSA producing the same derivatives.
  • Increased volatility of the reaction by-products over the non-fluorinated derivatives of BSA.
 

BSTFA w/1% TMCS

N,O-bis(Trimethylsilyl)trifluoroacetamide w/1% Trimethylchlorosilane

Part Number

SBSTFA-1-1

SBSTFA-1-10

SBSTFA-1-25

SBSTFA-1-100

 

 

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • Trimethylsilyl donor strength equal to BSA.
  • Reacts with the same classes of compounds as BSA. producing the same derivatives.
  • TMCS (Trimethylchlorosilane) added to derivatize amides, many secondary amines and hindered hydroxyls that are not reactive to BSTFA alone.
  • Increased volatility of the reaction by-products over the non-fluorinated derivatives of BSA.
 

BSTFA w/10% TMCS

N,O-bis(Trimethylsilyl)trifluoroacetamide w/10% Trimethylchlorosilane

Part Number

SBSTFA-10-1

SBSTFA-10-10

SBSTFA-10-25

SBSTFA-10-100

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • Trimethylsilyl donor strength equal to BSA.
  • Reacts with the same classes of compounds as BSA producing the same derivatives.
  • TMCS (Trimethylchlorosilane) added to derivatize amides, many secondary amines and hindered. hydroxyls that are not reactive to BSTFA alone.
  • Increased volatility of the reaction by-products over the non-fluorinated derivatives of BSA.
 

MSTFA

N-Methyl-N-trimethylsilyltrifluoroacetamide

Part Number

SMSTFA-0-1

SMSTFA-0-10

SMSTFA-0-25

SMSTFA-0-100

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • A trimethylsilyl adduct with donor strength equal to BSA and BSTFA.
  • Most volatile of the TMS derivatives.
  • Often elutes at the solvent front of the GC.

 

MSTFA w/1% TMCS

N-Methyl-N-trimethylsilyltrifluoroacetamide w/1% trimethylchlorosilane

Part Number

SMSTFA-1-1

SMSTFA-1-10

SMSTFA-1-25

SMSTFA-1-100

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • A trimethylsilyl adduct with donor strength equal to BSA and BSTFA.
  • Most volatile of the TMS derivatives.
  • Often elutes at the solvent front of the GC.
  • Addition of TMCS aids in the derivatization of amides, secondary amines and hindered Hydroxy groups.
 

MTBSTFA

N-Methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide

Part Number

SMTBSTFA-0-1

SMTBSTFA-0-10

SMTBSTFA-0-25

SMTBSTFA-0-100

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • Derivatizes hydroxyl, carboxyl, thiol and primary and secondary amines.
  • Derivatives are more stable than TMS derivatives to hydrolysis.
  • Reaction by-products are neutral and volatile.

 

MTBSTFA w/1% TBDMCS

N-Methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide  w/ 1% tert-butyldimethylchlorosilane

Part Number

SMTBSTFA-1-1

SMTBSTFA-1-10

SMTBSTFA-1-25

SMTBSTFA-1-100

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • Derivatizes hydroxyl, carboxyl, thiol and primary and secondary amines.
  • Addition of TBDMCS (tertiary butyl-dimethylchlorosilane) increases the silylation ability of this reagent to derivatize hindered alcohols and amines.
  • Derivatives are more stable than TMS derivatives to hydrolysis.
  • Reaction by-products are neutral and volatile.

 

MTBSTFA w/10% TBDMCS

N-Methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide

Part Number

SMTBSTFA-10-1

SMTBSTFA-10-10

SMTBSTFA-10-25

SMTBSTFA-10-100

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • Derivatizes hydroxyl, carboxyl, thiol and primary and secondary amines.
  • Addition of TBDMCS (tertiary butyl-dimethylchlorosilane) increases the silylation ability of this reagent to derivatize hindered alcohols and amines.
  • Derivatives are more stable than TMS derivatives to  hydrolysis.
  • Reaction by-products are neutral and volatile.

 

TMCS

Trimethylchlorosilane

Part Number

STMCS-0-1

STMCS-0-10

STMCS-0-25

STMCS-0-100

Quantity

1 gm vial

10 gm vial

25 gm vial

100 gm vial

Units per pack

10

1

1

1
  • Catalysts used to increase the reactivity of other silylation reagents.
  • Used to form trimethysilyl esters of organic acids.